Imaging

Optical Coherence Tomography (OCT) Goes From Bench to Bedside

With translational research, Carle is turning the latest knowledge into advanced medicine

In Carle Foundation Hospital’s operating room, Dr. Stephen Boppart is shedding new light – specifically, near-infrared light – on cancer detection.

Boppart and his team of University of Illinois scientists have developed a new approach to imaging that could help doctors detect tumors at the bedside. Similar in concept to ultrasound, optical coherence tomography (OCT) works by directing a beam of near-infrared light into tissue and measuring the density of the reflections (denser areas suggest tumors). To enhance existing OCT technology, UI researchers developed an injectable solution that emphasizes the contrast between normal fat cells and potential cancer cells.

The technology promises many benefits to patients. Physicians may be able to use the non-invasive technology to detect tumors at an earlier stage than is currently possible. Plus, it offers surgeons real-time feedback in the operating room.

“It can help surgeons know immediately if they’ve removed all of the cancer cells,” said Boppart, MD, a professor of electrical and computer engineering and of bioengineering at the University of Illinois. “That should help reduce patients’ anxiety and may save them from having to undergo another surgery.”

Breast cancer research is of particular interest since it will play a significant role in the Mills Breast Cancer Institute. The facility, opening in 2008, will devote an entire floor to research. There, scientists and Carle Clinic physicians will investigate hormone therapy, imaging, the role of genes in predicting breast cancer and caring for chronic health issues associated with breast cancer.